The project

The ORCHESTRA project provides an innovative approach to learn from the SARS-CoV-2 pandemic and derive recommendations for the management of COVID-19 and to be prepared for possible future pandemics.

The cohorts involved

By studying several homogeneous population groups, each with different characteristics (cohorts), the project aims to establish COVID-19 risk and protective factors plus vaccine efficacy and effectiveness.

The project builds upon existing and new large scale population cohorts in Europe and non-European countries. The ORCHESTRA cohorts include four components:

General population

9 large population-based cohorts (infected, not infected). The existing cohorts include a total of 440,000 individuals.

COVID-19 cohorts and long-term sequelae

10 cohorts. The existing cohorts include more than 11,500 records.

Fragile individuals

Elderly, children, pregnant women, HIV-infected, transplanted and those with Parkinson diseases or rheumatological diseases - infected and non-infected. The existing cohorts include a total of 18,000 records.

Health-care workers

Includes 9 cohorts (infected, not infected). The existing cohorts include a total of 80,000 records.

ORCHESTRA research objectives


ORCHESTRA has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101016167.